4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide
MS436
CAS: 1395084-25-9
Molecular Formula: C18H17N5O3S
4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide - Names and Identifiers
4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide - Physico-chemical Properties
| Molecular Formula | C18H17N5O3S |
| Molar Mass | 383.42 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Boling Point | 673.7±65.0 °C(Predicted) |
| Solubility | DMSO: 25.5 mg/mL |
| pKa | 9.25±0.36(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated K i of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of NO and pro-inflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. MS436 exhibits potent affinity of an estimated K i =30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2, which is achieved through a unique set of water-mediated intermolecular interactions. |
4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.608 ml | 13.04 ml | 26.081 ml |
| 5 mM | 0.522 ml | 2.608 ml | 5.216 ml |
| 10 mM | 0.261 ml | 1.304 ml | 2.608 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide - Introduction
MS436 is the name of a chemical that has not been widely documented or publicly studied, making it difficult to provide detailed information about it. There are very few reports of MS436 in chemical databases and literature, and it is likely that it is an uncommon compound or that there is very little research in progress.
Last Update：2024-04-09 20:49:11
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Product Name: MS436 Visit Supplier Webpage Request for quotationCAS: 1395084-25-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide
4-(4-氟苯基)-3-甲基-1H-吡唑-5-胺
Diallyl monooxide
4-(4-氟苯基)-3-甲基-1H-吡唑-5-胺
Diallyl monooxide